LEUKEMIA MEDIATED ENDOTHELIAL CELL ACTIVATION MODULATES LEUKEMIA CELL SUSCEPTIBILITY TO CHEMOTHERAPY THROUGH A POSITIVE FEEDBACK LOOP MECHANISM.

Leukemia Mediated Endothelial Cell Activation Modulates Leukemia Cell Susceptibility to Chemotherapy through a Positive Feedback Loop Mechanism.

In acute myeloid leukemia (AML), the chances of achieving disease-free survival are low.Studies have demonstrated a supportive role of endothelial cells (ECs) in normal hematopoiesis.Here we show that similar intercellular relationships exist in leukemia.We demonstrate that leukemia cells themselves initiate these interactions by directly modulatin

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Collagen Type I as a Ligand for Receptor-Mediated Signaling

Collagens form the fibrous component of the extracellular matrix in all multi-cellular animals.Collagen type I is the most abundant collagen present in skin, tendons, vasculature, as well as the organic portion of the calcified tissue of bone and teeth.This review focuses on numerous receptors for which collagen acts as a ligand, including integrin

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