Leukemia Mediated Endothelial Cell Activation Modulates Leukemia Cell Susceptibility to Chemotherapy through a Positive Feedback Loop Mechanism.
In acute myeloid leukemia (AML), the chances of achieving disease-free survival are low.Studies have demonstrated a supportive role of endothelial cells (ECs) in normal hematopoiesis.Here we show that similar intercellular relationships exist in leukemia.We demonstrate that leukemia cells themselves initiate these interactions by directly modulatin